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Pre-Launch – Request Early Access

Upload your 10993 package and get a scored gap report.

See where your biological evaluation has gaps, what justifications are weak, and what to strengthen before your notified body or FDA submission. BioEvalPro evaluates your documentation section by section, scored against ISO 10993 and both EU MDR and FDA expectations. Reports delivered in 1 to 2 business days.

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Find gaps before submission. Speed up expert review.

BioEvalPro reads your biological evaluation documentation, flags where claims are unsupported or inconsistent, and shows you what to fix before the notified body sees it.

Gap Detection
Finds missing content, incomplete sections, and unsupported conclusions before submission.
Conflict Flagging
Flags contradictions and inconsistencies across your BEP, BER, and supporting documents.
Unsupported Claim Identification
Shows where conclusions aren't backed by referenced data, testing, or rationale.
Justification Strength Scoring
Scores every justification for specificity, traceability, and evidence quality. Generic or circular rationale is flagged with guidance on what to strengthen.
Remediation Guidance
Specific suggestions for strengthening each flagged section.
2018 → 2025 Transition Detection
Identifies which 2025 requirements your existing documentation doesn't yet address.

Simplified Report Preview

BioEvalPro Gap Analysis Report
72
Readiness Score
3 areas need attention
BEP Completeness PASS
Chemical Characterization (10993-18) PASS
Toxicological Risk Assessment (10993-17) FLAG
Risk Management Integration FAIL
2025 Version Compliance FLAG
Foreseeable Misuse Coverage FAIL
Justification Strength FLAG
What gets evaluated across the 10993 series.

Each area scored Pass, Flag, or Fail with an explanation and remediation guidance.

Biological Evaluation Plan Part 1
Strategy justification, endpoint selection, and rationale completeness.
Biological Evaluation Report Part 1
Overall coherence against ISO 10993-1:2025 requirements.
Chemical Characterization Part 18
Material identification, extractable/leachable coverage.
Cytotoxicity Part 5
Test documentation and result interpretation.
Sensitization & Irritation Part 10
Protocol and endpoint documentation.
Genotoxicity Part 3
Risk justification and test selection rationale.
Hemocompatibility Part 4
Blood interaction testing selection and documentation for devices contacting the cardiovascular system.
Implantation Part 6
Local tissue response evaluation for implantable devices.
Systemic Toxicity Part 11
Acute, subacute, and subchronic systemic toxicity evaluation and justification.
Sample Preparation & Reprocessing Part 12
Extraction conditions, test article preparation, reprocessing simulation, and timepoint selection for reusable devices.
Toxicological Risk Assessment Part 17
TRA methodology and tolerable exposure calculations.
ISO 14971 Risk Integration 2025
Risk management file cross-referencing: severity, probability, uncertainty.
Foreseeable Misuse 2025
Documentation of misuse scenarios and their biological safety implications.
2018 to 2025 Transition Gap Flagging Transition
Identifies elements compliant with 2018 but deficient under the 2025 standard.

The evaluation framework draws from core ISO 10993 standards, published FDA and EU MDCG guidance, and documented notified body review patterns. Learn how BioEvalPro fits into your team's workflow →

A structured first pass so your experts can focus on what matters.
Your documentation is handled with care.

Enterprise-grade infrastructure built for regulated industries.

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Encryption in transit and at rest
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Secure portal to access your documents and reports
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GDPR compliant. DPA available
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NDA available
Practical guidance for ISO 10993 documentation.

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Frequently Asked Questions
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Does this replace my regulatory consultant or toxicologist?
No. BioEvalPro evaluates documentation quality and flags gaps. Device-specific scientific judgment calls remain with your regulatory team, toxicologist, or contracted experts.
Which version of ISO 10993-1 does it evaluate against?
The 2025 standard, with full 2018-to-2025 delta awareness. Select your evaluation type and the analysis adjusts accordingly.
What file formats do you accept?
PDF and Word (.docx). Individual documents or a complete package.
How is my documentation handled?
Encrypted in transit and at rest. Stored in a secure portal where you can access your documents and reports at any time. GDPR compliant, DPA available on request.
How much does it cost?
Per-submission and subscription options. Pricing is being finalized ahead of launch. Contact us for details.
How long does the evaluation take?
1 to 2 business days. Full section-by-section scoring with explanations and remediation steps.
Can it check my Clinical Evaluation Report too?
CER gap scanning is on the roadmap. Launch focuses on core ISO 10993 biological evaluation documentation.
Request a gap analysis or ask us anything.

Tell us about your project, request a biological evaluation gap analysis, or ask a question. We will get back to you within one business day.

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